Philip Jeremiah Schuyler (1768–1835) was an American politician and agriculturalist from New York. The son of Revolutionary War general Philip Schuyler, he served one term as a Federalist in the United States House of Representatives from 1817 to 1819.

Cortlandt Van Rensselaer Schuyler (1900–1993) was a United States Army general who served in both World War I and World War II and later played a key role in early NATO military planning. Rising to the rank of four-star general, he served as Chief of Staff at SHAPE headquarters in Paris before retiring from active military service in 1959.

Pieter Schuyler (1657–1724) was a colonial leader in early New York and the first mayor of Albany after the city was incorporated in 1686. A military officer and diplomat with the Haudenosaunee (Iroquois) nations, he later served twice as acting governor of the Province of New York.

Pieter Schuyler (1657–1724) was a colonial leader in early New York and the first mayor of Albany after the city was incorporated in 1686. A military officer and diplomat with the Haudenosaunee (Iroquois) nations, he later served twice as acting governor of the Province of New York.

Karl C. Schuyler (1877–1933) was an American lawyer and Republican politician who briefly served as a United States Senator from Colorado from December 1932 to March 1933. His short term filled a vacancy caused by the death of Senator Charles W. Waterman.

James Schuyler (1923–1991) was an American poet associated with the New York School of poets. Known for his reflective and observational style, he received the 1981 Pulitzer Prize for Poetry for his collection The Morning of the Poem.

Robert H. Schuller (1926–2015) was an American televangelist and pastor who founded the Crystal Cathedral in Garden Grove, California, and created the global television ministry Hour of Power. Known for his positive-thinking sermons and innovative church leadership, he built one of the most influential megachurch ministries of the twentieth century.

Leonard Schrader (1943–2006) was an American screenwriter, director, and author known for films such as The Yakuza and Kiss of the Spider Woman. Often collaborating with his brother, filmmaker Paul Schrader, he also taught screenwriting and wrote works in both English and Japanese.

Hubert J. P. Schoemaker (1950–2006) was a Dutch-born American biochemist and biotechnology entrepreneur who co-founded Centocor, one of the pioneering biotechnology companies in the United States. He later founded Neuronyx and helped develop the drug Remicade for autoimmune diseases.

Maarten Schmidt (1929–2022) was a Dutch-American astronomer who identified the first quasar in 1963, revealing that these powerful objects were extremely distant and energetic sources associated with massive black holes. His discovery transformed modern astrophysics and the understanding of the universe.

Abraham Maas Schermerhorn (1791–1855) was an American lawyer and politician who served two terms as a U.S. Representative from New York from 1849 to 1853. A Whig, he was also active in Rochester politics, serving as mayor and as a member of the New York State Senate.

Robert Cumming Schenck (1809–1890) was an American lawyer, politician, and Union Army general. He served multiple terms in the U.S. House of Representatives, rose to major general during the Civil War, and later served as U.S. Minister to the United Kingdom.